Volatile solvents
Volatile solvents refer to a large group of chemical compounds found in countless household and industrial products (e.g., nail polish remover, butane, paint thinners, paint, glue, gasoline, lighter fluid, correction fluid, markers, hair spray, aerosol deodorants, non-stick cooking sprays, aerosol computer cleaning products, refrigerants and certain cleaning fluids, to name but a few).
| Synonyms | Highly varied class of substances many of which are derived from oil and natural gas. The most common substances are:
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|---|---|
| Classification | Central nervous system depressant:
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| Visual description |
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| Mechanism of action |
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| Routes of administration | These substances are inhaled and several methods can be used:
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Effects sought out by the user
- Auditory, visual and tactile hallucinations
- Drowsiness (after the initial euphoria)
- Initial euphoria, disinhibition (5 to 45 minutes)
Common toxic effects
- Confusion
- Disorientation
- Distortion of perception of the size of objects
- Dizziness
- Drowsiness
- Eye, nose and throat irritations
- Generalized muscle weakness
- Headache
- Hypotension
- Inappropriate or aggressive behaviour
- Incoherent ideas and thoughts (impaired judgement)
- Nausea and vomiting
- Nystagmus (abnormal and repetitive eye movement)
- Partial or total memory loss
- Persistent bad breathe
- Slurred speech
- Stomach cramps and diarrhea
- Stupor (inertia and insensivity, general numbness)
- Tinnitus (ringing in the ears)
- Uncoordinated movements
- Unsteady gait
Overdose effects
- Arrhythmias (irregular heart beat), bradycardia
- Asphyxia
- Coma
- Convulsions
- Numbness
- Respiratory depression
- Sudden death (as a result of cardiac arrest - butane and propane are the most commonly used substances)
Effects associated with chronic use
- Antisocial behaviour
- Blindness
- Cognitive deficiencies, attention and concentration problems, problems with vision and short-term memory
- Depression
- Emphysema
- Emotional instability
- Hepatic and renal impairment
- Loss of energy
- Weight loss
- Psychosis
- Muscle spasms
- Hearing loss
- Heart failure
- Behavioural disorders
- Blood disorders (leukemia)
Tolerance (need to increase the dose to feel the same effect)
Tolerance develops gradually after frequent use.
Addiction
Physical dependence is infrequent and is usually mild, while psychological dependence is relatively infrequent.
Withdrawal
Possible, but rare. Symptoms are similar to those seen with other CNS depressants (e.g., opioids):
- Abnormal drowsiness
- Anxiety
- Confusion
- Depression
- Dizziness
- Excessive sweating
- Hallucinations
- Headache
- Irritability
- Loss of appetite
- Muscle cramps
- Nausea
- Sleep problems
- Tremor
| Route of administration | Onset of action | Peak | Duration ofaction |
|---|---|---|---|
| Inhalation | Very fast, effects are almost instant | A few minutes | Usually, from 5 to 30 minutes, rarely up to an hour |
Intoxication management
- No antidote available.
- Treatment is mainly symptomatic.
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The patient information leaflets are provided by Vigilance Santé Inc. This content is for information purposes only and does not in any manner whatsoever replace the opinion or advice of your health care professional. Always consult a health care professional before making a decision about your medication or treatment.